Welcome to the Finkelstein Lab

The Finkelstein lab is focused on understanding how our cells are able to stave off genomic instability and avoid cancer. Our highly interdisciplinary research program combines aspects of single-molecule biophysics, traditional biochemistry and micro-/nano-scale engineering to directly observe the key biochemical steps of DNA maintenance. We address fundamental questions regarding how cells coordinate multi-protein assemblies on DNA, how these biochemical reactions occur on chromatin, a highly condensed DNA-protein substrate, and how defects in these pathways lead to genomic instability.

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