We develop new biophysical methods to understand how molecular machines edit and repair our genomes. Current lab interests include CRISPR-cas adaptive immunity and eukaryotic DNA repair.

News

May 12, 2023: Dr. Jim Rybarski departs the lab to work at Moderna in Boston, MA. Congratulations!

April 21, 2023: You-Chiun Chang joins the lab!

February 10, 2023: Dr. Ilya Finkelstein is one of the six Functional Genomics Awardees !

January 30, 2023: Wei-Che Tseng joins the Finkelstein lab as a rotation student!

January 1, 2023: Selma Sinan joins the Finkelstein lab as a research scientist!

Recent Papers
High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

Kaur et al.

Published 28 Sep 2023
Asgard archaea defense systems and their roles in the origin of immunity in eukaryotes

Leão et al. BioRxiv (2023)

Published 13 Sep 2023
CTCF and R-loops are boundaries of cohesin-mediated DNA looping

Zhang et al. Mol. Cell (2022)

Published 17 Aug 2023
Unraveling the mechanisms of PAMless DNA interrogation by SpRY Cas9

Hibshman et al. BioRxiv (2023)

Published 22 Jun 2023