Brandolini's World
October 6, 2026
We're all learning Brandolini's law: The amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it.
Blog
Thoughts on science, methods, and tools
Harvesting and Replenishment in Biomedicine
September 28, 2026
Anthropic's agents found an interesting enzyme system in a public database, or maybe not.
The New NIH Scoring Rubric: 👍 🤷♂️ 😂
September 1, 2026
BETHESDA, MD—The National Institutes of Health announced Tuesday that it would replace its 50-year-old numerical scoring system with a streamlined three-emoji format, in which grant applications will receive either a thumbs up (👍), a shrug (🤷♂️), or a laughing face (😂).
“The old system created a false sense of precision,” said NIH Director Jay Bhattacharya. “A researcher would get a 23 and think, how is my grant different from a 27? Now there’s clarity. You get a thumbs up, you’re in the conversation. You get a shrug, it could go either way. You get crying laughter, well, you know where you stand.” […]
— In Preparation, satirical science news, in the spirit of The Onion
Claude vs Printer Android Bridge
August 28, 2026
Rescuing an old Brother laser printer so it can print from Android phones, with Claude Code doing the heavy lifting.