Tags

• Optical phase matching 1
• Vibration analysis 1
• Proteins 1
• Horseradish peroxidase 1
• Ultrafast 1
• Infrared spectra 1
• Diffusion 3
• Correlation functions 1
• Fourier transforms 1
• Myoglobin mutants 1
• Protein dynamics 1
• Energy landscape 1
• DNA 11
• Lipid bilayers 1
• Nucleosomes 4
• Escheria coli proteins 2
• Membrane proteins 1
• Nucleic acid conformation 1
• Single stranded DNA 1
• DNA-binding proteins 3
• Microscopy 4
• Protein Binding 1
• Replication Protein A 2
• Bacterial proteins 1
• RNA polymerase 1
• Kinetics 1
• Promoter Regions 1
• Transcription 2
• Helicases 1
• DNA repair 8
• DNA replication 3
• Cell cycle proteins 1
• HEK293 cells 1
• Ubiquitin 1
• Microfluidics 4
• Binding sites 1
• Lambda phage 1
• Protein structure 1
• Protein transport 1
• Aging 2
• Cellular senescence 2
• Computational biology 1
• High-throughput screening assays 1
• Protein binding 1
• Spectrum analysis 1
• Nanotechnology 1
• Chromatin 1
• Histones 1
• MutS Homolog 2 1
• MutS Homolog 3 1
• Biocatalysis 1
• DNA damage 1
• Exodeoxyribonucleases 1
• ATP-dependent protease 1
• intrinsically disordered protein 1
• proteasome 1
• protein degradation 1
• protein stability 1
• protein targeting 1
• ubiquitylation 1
• DNA curtains 8
• Nicking enzyme 1
• Recombineering 1
• Single-molecule imaging 3
• Homologous recombination 3
• S. pombe 2
• Biophysics 1
• Cell biology 1
• Fission yeast 1
• Replicative lifespan 1
• Structural biology 1
• Cascade 2
• CHAMP 1
• CRISPR 7
• DNA double-stranded breaks 1
• Eukaryota 1
• MRN 2
• Cellular aging 1
• Fabrication 1
• Lifespan 1
• Lithography 1
• Microdissection 1
• Genome integrity 1
• DNA barcodes 1
• Error-correcting codes 1
• Information storage 1
• Massively parallel synthesis 1
• Cellular identity 1
• Chromosomes 1
• Epigentic inheritance 1
• Gene expression 1
• Heterochromatin spreading 1
• Multigenerational single cell tracking 1
• AsCpf1 1
• CRISPR-Cas system 1
• RNA-guided nuclease 1
• Rate-limiting binding 1
• single molecule; DNA curtain; RPA 1
• SSB 1
• rolling circle replication 1
• DNA Curtains 2
• fluorescence microscopy 1
• primed acquisition 1
• phage MuGam 1
• NHEJ 1
• RecBCD 1
• E. coli ligase 1
• Intrinsically disordered regions 1
• chromatin 2
• facilitated diffusion 1
• mismatch repair 1
• Mlh1-Pms1 1
• sortase 1
• cascade 1
• cas3 1
• cas1–cas2 1
• protein labeling 1
• fluorescence 1
• Bloom's syndrome helicase(BLM) 1
• DNA nuclease (DNA2) 1
• Exonuclease 1 (EXO1) 1
• end resection 1
• RPA 1
• phosphorylated RPA 1
• BLM helicase 1
• CRISPR-Cas; E. coli; S. pyogenes; anti-CRISPR; bacterial defense systems; functional metagenomics; human; human microbiome; infectious disease; microbiology; phage 1
• ribonucleoprotein complex 1
• RNP 1
• RNA binding protein 1
• RBP 1
• proteomics 1
• DIFFRAC 1
• protein complexes 1
• biochemical fractionation 1
• mass spectrometry 1
• interactome 1
• Reed-Solomon 1
• error-correcting code 1
• indel 1
• information storage 1
• COVID-19 1
• COVID-19 disease 1
• SARS-CoV-2 1
• evolution 1
• genome sequencing 1
• molecular population genomics 1
• gene editing 2
• bioinformatics 1
• CAST 1
• transposition 2
• CRISPR RNA 1
• SF2 helicase 1
• RAD51 1
• PARP-1 1
• PARylation 1
• single-molecule 5
• liquid-liquid phase separation 1
• single molecule DNA collapse 1
• biomolecular condensates 1
• salt effects 1
• DNA resection 1
• double-strand break 1
• single molecule 1
• BLMDNA2 1
• bacterial defense 1
• selfish genetic element 1
• phase separation 1
• biomolecular condensate 1
• cohesin 1
• CTCF 1
• R-loop 1
• cryo-EM 2
• TADs 1
• 3D genome 1
• High-speed AFM imaging 1
• cohesin DNA binding and loop extrusion 1
• protein-DNA interaction dynamics 1
• multi-subunit protein complexes 1
• protein conformational changes 1
• Mammalian Antigen Display 1
• Pandemic 1
• RNA-targeting CRISPR-Cas13d 1
• CRISPR-Cas 1
• CRISPR-Cas12a 1
• Kinetic 1
• ADP-Ribosylation 1
• Biomolecular Condensates 1
• DNA Repair 1
• PARP1 1
• Phase Separation 1
• Cas12a 3
• diagnostics 3
• room temperature 1
• Anti-CRISPR 1
• Acr 1
• heterochromatin 1
• subtelomere 1
• epigenetics 1
• fission yeast 1
• retron 1
• genome editing 1
• isothermal amplification 1
• anti-phage defense 1
• abortive infection 1
• nuclease 2
• DNase I 1
• atomic force microscopy 1
• Cas13d structure 1

Optical phase matching

• Fifth-order contributions to ultrafast spectrally resolved vibrational echoes: heme-CO proteins.

Vibration analysis

• Fifth-order contributions to ultrafast spectrally resolved vibrational echoes: heme-CO proteins.

Proteins

• Fifth-order contributions to ultrafast spectrally resolved vibrational echoes: heme-CO proteins.

Horseradish peroxidase

• Substrate binding and protein conformational dynamics measured by 2D-IR vibrational echo spectroscopy.

Ultrafast

• Substrate binding and protein conformational dynamics measured by 2D-IR vibrational echo spectroscopy.

Infrared spectra

• Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: a new approach.

Diffusion

• The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.
• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.
• Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: a new approach.

Correlation functions

• Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: a new approach.

Fourier transforms

• Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: a new approach.

Myoglobin mutants

• Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy.

Protein dynamics

• Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy.

Energy landscape

• Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy.

DNA

• HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints
• Eukaryotic resectosomes: A single-molecule perspective.
• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
• High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.
• High-throughput single-molecule studies of protein-DNA interactions.
• Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.
• Rapid prototyping of multichannel microfluidic devices for single-molecule DNA curtain imaging.
• Molecular traffic jams on DNA.
• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.
• Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.
• Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.

Lipid bilayers

• Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.

Nucleosomes

• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
• Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
• Molecular traffic jams on DNA.
• Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.

Escheria coli proteins

• Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.
• Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.

Membrane proteins

• Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.

Nucleic acid conformation

• Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.

Single stranded DNA

• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.

DNA-binding proteins

• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
• Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.

Microscopy

• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.
• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
• High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.
• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.

Protein Binding

• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.

Replication Protein A

• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.

Bacterial proteins

• The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.

RNA polymerase

• The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.

Kinetics

• The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.

Promoter Regions

• The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.

Transcription

• Molecular traffic jams on DNA.
• The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.

Helicases

• Molecular traffic jams on DNA.

DNA repair

• RPA phosphorylation inhibits DNA resection
• Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
• Coordination of Rad1-Rad10 interactions with Msh2-Msh3, Saw1 and RPA is essential for functional 3' non-homologous tail removal.
• Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
• Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.
• Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.
• Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
• Molecular traffic jams on DNA.

DNA replication

• How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
• Coordination of Rad1-Rad10 interactions with Msh2-Msh3, Saw1 and RPA is essential for functional 3' non-homologous tail removal.
• Molecular traffic jams on DNA.

Cell cycle proteins

• Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

HEK293 cells

• Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Ubiquitin

• Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Microfluidics

• A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.
• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.
• 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.
• Rapid prototyping of multichannel microfluidic devices for single-molecule DNA curtain imaging.

Binding sites

• Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.

Lambda phage

• Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.

Protein structure

• Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.

Protein transport

• Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.

Aging

• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.
• From cradle to grave: high-throughput studies of aging in model organisms.

Cellular senescence

• 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.
• From cradle to grave: high-throughput studies of aging in model organisms.

Computational biology

• From cradle to grave: high-throughput studies of aging in model organisms.

High-throughput screening assays

• 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.

Protein binding

• High-throughput single-molecule studies of protein-DNA interactions.

Spectrum analysis

• High-throughput single-molecule studies of protein-DNA interactions.

Nanotechnology

• High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.

Chromatin

• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.

Histones

• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.

MutS Homolog 2

• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.

MutS Homolog 3

• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.

Biocatalysis

• Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

DNA damage

• Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

Exodeoxyribonucleases

• Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

ATP-dependent protease

• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

intrinsically disordered protein

• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

proteasome

• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

protein degradation

• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

protein stability

• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

protein targeting

• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

ubiquitylation

• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

DNA curtains

• The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins
• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
• Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
• Assembling the Human Resectosome on DNA Curtains.
• Sortase-mediated fluorescent labeling of CRISPR complexes
• Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
• Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.
• Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.

Nicking enzyme

• Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.

Recombineering

• Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.

Single-molecule imaging

• Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
• Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.
• Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.

Homologous recombination

• Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
• Assembling the Human Resectosome on DNA Curtains.
• Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.

S. pombe

• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.
• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Biophysics

• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Cell biology

• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Fission yeast

• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Replicative lifespan

• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Structural biology

• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Cascade

• Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.
• Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips

CHAMP

• Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips

CRISPR

• One-Pot Isothermal Linear Amplification and Cas12a-Based Nucleic Acid Detection
• Discovery and engineering of retrons for precise genome editing
• Unleashing high trans-substrate cleavage kinetics of Cas12a for nucleic acid diagnostics
• Room temperature CRISPR diagnostics for low-resource settings
• Sortase-mediated fluorescent labeling of CRISPR complexes
• Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.
• Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips

DNA double-stranded breaks

• Eukaryotic resectosomes: A single-molecule perspective.

Eukaryota

• Eukaryotic resectosomes: A single-molecule perspective.

MRN

• Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
• Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair

Cellular aging

• A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.

Fabrication

• A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.

Lifespan

• A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.

Lithography

• A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.

Microdissection

• A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.

Genome integrity

• Coordination of Rad1-Rad10 interactions with Msh2-Msh3, Saw1 and RPA is essential for functional 3' non-homologous tail removal.

DNA barcodes

• Indel-correcting DNA barcodes for high-throughput sequencing.

Error-correcting codes

• Indel-correcting DNA barcodes for high-throughput sequencing.

Information storage

• Indel-correcting DNA barcodes for high-throughput sequencing.

Massively parallel synthesis

• Indel-correcting DNA barcodes for high-throughput sequencing.

Cellular identity

• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.

Chromosomes

• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.

Epigentic inheritance

• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.

Gene expression

• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.

Heterochromatin spreading

• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.

Multigenerational single cell tracking

• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.

AsCpf1

• Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.

CRISPR-Cas system

• Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.

RNA-guided nuclease

• Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.

Rate-limiting binding

• Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.

single molecule; DNA curtain; RPA

• Assessing Protein Dynamics on Low-Complexity Single-Stranded DNA Curtains.

SSB

• Assessing Protein Dynamics on Low-Complexity Single-Stranded DNA Curtains.

rolling circle replication

• Assessing Protein Dynamics on Low-Complexity Single-Stranded DNA Curtains.

DNA Curtains

• Mechanism of Cas9 inhibition by AcrIIA11
• Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.

fluorescence microscopy

• Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.

primed acquisition

• Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.

phage MuGam

• Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

NHEJ

• Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

RecBCD

• Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

E. coli ligase

• Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

Intrinsically disordered regions

• Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.

chromatin

• In Diverse Conditions, Intrinsic Chromatin Condensates Have Liquid-like Material Properties
• Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.

facilitated diffusion

• Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.

mismatch repair

• Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.

Mlh1-Pms1

• Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.

sortase

• Sortase-mediated fluorescent labeling of CRISPR complexes

cascade

• Sortase-mediated fluorescent labeling of CRISPR complexes

cas3

• Sortase-mediated fluorescent labeling of CRISPR complexes

cas1–cas2

• Sortase-mediated fluorescent labeling of CRISPR complexes

protein labeling

• Sortase-mediated fluorescent labeling of CRISPR complexes

fluorescence

• Sortase-mediated fluorescent labeling of CRISPR complexes

Bloom's syndrome helicase(BLM)

• Assembling the Human Resectosome on DNA Curtains.

DNA nuclease (DNA2)

• Assembling the Human Resectosome on DNA Curtains.

Exonuclease 1 (EXO1)

• Assembling the Human Resectosome on DNA Curtains.

end resection

• RPA phosphorylation inhibits DNA resection

RPA

• RPA phosphorylation inhibits DNA resection

phosphorylated RPA

• RPA phosphorylation inhibits DNA resection

BLM helicase

• RPA phosphorylation inhibits DNA resection

CRISPR-Cas; E. coli; S. pyogenes; anti-CRISPR; bacterial defense systems; functional metagenomics; human; human microbiome; infectious disease; microbiology; phage

• Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

ribonucleoprotein complex

• Systematic discovery of endogenous human ribonucleoprotein complexes

RNP

• Systematic discovery of endogenous human ribonucleoprotein complexes

RNA binding protein

• Systematic discovery of endogenous human ribonucleoprotein complexes

RBP

• Systematic discovery of endogenous human ribonucleoprotein complexes

proteomics

• Systematic discovery of endogenous human ribonucleoprotein complexes

DIFFRAC

• Systematic discovery of endogenous human ribonucleoprotein complexes

protein complexes

• Systematic discovery of endogenous human ribonucleoprotein complexes

biochemical fractionation

• Systematic discovery of endogenous human ribonucleoprotein complexes

mass spectrometry

• Systematic discovery of endogenous human ribonucleoprotein complexes

interactome

• Systematic discovery of endogenous human ribonucleoprotein complexes

Reed-Solomon

• HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints

error-correcting code

• HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints

indel

• HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints

information storage

• HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints

COVID-19

• Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

COVID-19 disease

• Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

SARS-CoV-2

• Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

evolution

• Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

genome sequencing

• Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

molecular population genomics

• Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

gene editing

• Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons
• Metagenomic Discovery of CRISPR-Associated Transposons

bioinformatics

• Metagenomic Discovery of CRISPR-Associated Transposons

CAST

• Metagenomic Discovery of CRISPR-Associated Transposons

transposition

• Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons
• Metagenomic Discovery of CRISPR-Associated Transposons

CRISPR RNA

• Metagenomic Discovery of CRISPR-Associated Transposons

SF2 helicase

• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

RAD51

• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

PARP-1

• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

PARylation

• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

single-molecule

• Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy
• Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system
• Mechanism of Cas9 inhibition by AcrIIA11
• CTCF and R-loops are boundaries of cohesin-mediated DNA looping
• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

liquid-liquid phase separation

• How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

single molecule DNA collapse

• How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

biomolecular condensates

• How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

salt effects

• How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

DNA resection

• The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins

double-strand break

• The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins

single molecule

• The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins

BLMDNA2

• The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins

bacterial defense

• Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons

selfish genetic element

• Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons

phase separation

• In Diverse Conditions, Intrinsic Chromatin Condensates Have Liquid-like Material Properties

biomolecular condensate

• In Diverse Conditions, Intrinsic Chromatin Condensates Have Liquid-like Material Properties

cohesin

• CTCF and R-loops are boundaries of cohesin-mediated DNA looping

CTCF

• CTCF and R-loops are boundaries of cohesin-mediated DNA looping

R-loop

• CTCF and R-loops are boundaries of cohesin-mediated DNA looping

cryo-EM

• Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system
• CTCF and R-loops are boundaries of cohesin-mediated DNA looping

TADs

• CTCF and R-loops are boundaries of cohesin-mediated DNA looping

3D genome

• CTCF and R-loops are boundaries of cohesin-mediated DNA looping

High-speed AFM imaging

• High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

cohesin DNA binding and loop extrusion

• High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

protein-DNA interaction dynamics

• High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

multi-subunit protein complexes

• High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

protein conformational changes

• High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

Mammalian Antigen Display

• Mammalian Antigen Display for Pandemic Countermeasures

Pandemic

• Mammalian Antigen Display for Pandemic Countermeasures

RNA-targeting CRISPR-Cas13d

• Massively Parallel Profiling of RNA-targeting CRISPR-Cas13d

CRISPR-Cas

• Massively Parallel Profiling of RNA-targeting CRISPR-Cas13d

CRISPR-Cas12a

• Kinetic dissection of pre-crRNA binding and processing by CRISPR-Cas12a

Kinetic

• Kinetic dissection of pre-crRNA binding and processing by CRISPR-Cas12a

ADP-Ribosylation

• PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Biomolecular Condensates

• PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

DNA Repair

• PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

PARP1

• PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Phase Separation

• PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Cas12a

• One-Pot Isothermal Linear Amplification and Cas12a-Based Nucleic Acid Detection
• Unleashing high trans-substrate cleavage kinetics of Cas12a for nucleic acid diagnostics
• Room temperature CRISPR diagnostics for low-resource settings

diagnostics

• One-Pot Isothermal Linear Amplification and Cas12a-Based Nucleic Acid Detection
• Unleashing high trans-substrate cleavage kinetics of Cas12a for nucleic acid diagnostics
• Room temperature CRISPR diagnostics for low-resource settings

room temperature

• Room temperature CRISPR diagnostics for low-resource settings

Anti-CRISPR

• Mechanism of Cas9 inhibition by AcrIIA11

Acr

• Mechanism of Cas9 inhibition by AcrIIA11

heterochromatin

• Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

subtelomere

• Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

epigenetics

• Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

fission yeast

• Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

retron

• Discovery and engineering of retrons for precise genome editing

genome editing

• Discovery and engineering of retrons for precise genome editing

isothermal amplification

• One-Pot Isothermal Linear Amplification and Cas12a-Based Nucleic Acid Detection

anti-phage defense

• Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system

abortive infection

• Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system

nuclease

• Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy
• Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system

DNase I

• Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy

atomic force microscopy

• Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy

Cas13d structure

• Structural basis for target discrimination and activation by Cas13d