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papers
- Structural basis for target discrimination and activation by Cas13d
- Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy
- Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system
- One-Pot Isothermal Linear Amplification and Cas12a-Based Nucleic Acid Detection
- Discovery and engineering of retrons for precise genome editing
- Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
- Unleashing high trans-substrate cleavage kinetics of Cas12a for nucleic acid diagnostics
- Mechanism of Cas9 inhibition by AcrIIA11
- Room temperature CRISPR diagnostics for low-resource settings
- PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
- Kinetic dissection of pre-crRNA binding and processing by CRISPR-Cas12a
- Massively Parallel Profiling of RNA-targeting CRISPR-Cas13d
- Mammalian Antigen Display for Pandemic Countermeasures
- High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL
- Asgard archaea defense systems and their roles in the origin of eukaryotic immunity
- CTCF and R-loops are boundaries of cohesin-mediated DNA looping
- Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
- In Diverse Conditions, Intrinsic Chromatin Condensates Have Liquid-like Material Properties
- Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons
- The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins
- Massively Parallel Selection of NanoCluster Beacons
- Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein
- How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
- Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
- A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
- Compartmentalization of telomeres through DNA-scaffolded phase separation
- Rapid characterization of spike variants via mammalian cell surface display
- Metagenomic Discovery of CRISPR-Associated Transposons
- Opfi: A Python package for identifying gene clusters in large genomics and metagenomics data sets
- Expression and characterization of SARS-CoV-2 Spike Proteins
- Characterization of the T4 gp32-ssDNA complex by native, cross-linking, and ultraviolet photodissociation mass spectrometry
- Disintegration promotes proto-spacer integration by the Cas1-Cas2 complex
- Trajectory of Growth of SARS-CoV-2 Variants in Houston, Texas, January through May 2021 Based on 12,476 Genome Sequences
- Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
- CRISPR-guided programmable self-assembly of artificial virus-like nucleocapsids
- Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
- Inhibition of CRISPR-Cas12a DNA Targeting by Nucleosomes and Chromatin
- Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area
- Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
- Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements
- Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes
- HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints
- RADX condenses single-stranded DNA to antagonize RAD51 loading
- DNA-dependent Protein Kinase Promotes DNA End Processing by MRN and CtIP
- Human cohesin compacts DNA by loop extrusion
- Systematic discovery of endogenous human ribonucleoprotein complexes
- Retrons and their applications in genome engineering
- Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
- RPA phosphorylation inhibits DNA resection
- Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
- Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
- Assembling the Human Resectosome on DNA Curtains.
- Sortase-mediated fluorescent labeling of CRISPR complexes
- Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.
- Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase
- Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.
- Assessing Protein Dynamics on Low-Complexity Single-Stranded DNA Curtains.
- Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.
- Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.
- Indel-correcting DNA barcodes for high-throughput sequencing.
- Coordination of Rad1-Rad10 interactions with Msh2-Msh3, Saw1 and RPA is essential for functional 3' non-homologous tail removal.
- Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair.
- A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.
- Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
- Eukaryotic resectosomes: A single-molecule perspective.
- Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips
- Efficient modification of λ-DNA substrates for single-molecule studies.
- An aging-independent replicative lifespan in a symmetrically dividing eukaryote.
- Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.
- Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.
- Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.
- Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.
- Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
- High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.
- High-throughput single-molecule studies of protein-DNA interactions.
- 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.
- From cradle to grave: high-throughput studies of aging in model organisms.
- Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.
- Rapid prototyping of multichannel microfluidic devices for single-molecule DNA curtain imaging.
- Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
- Molecular traffic jams on DNA.
- The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.
- Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.
- Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.
- Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.
- Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase.
- XPD helicase speeds through a molecular traffic jam.
- Single molecule studies of homologous recombination.
- Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy.
- Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: a new approach.
- Viscosity-Dependent Protein Dynamics
- Probing dynamics of complex molecular systems with ultrafast 2D IR vibrational echo spectroscopy.
- Substrate binding and protein conformational dynamics measured by 2D-IR vibrational echo spectroscopy.
- Cytochrome c552 mutants: structure and dynamics at the active site probed by multidimensional NMR and vibration echo spectroscopy.
- Dynamics of proteins encapsulated in silica sol-gel glasses studied with IR vibrational echo spectroscopy.
- The influence of aqueous versus glassy solvents on protein dynamics: vibrational echo experiments and molecular dynamics simulations.
- Ultrafast dynamics of myoglobin without the distal histidine: stimulated vibrational echo experiments and molecular dynamics simulations.
- Dynamics of hemoglobin in human erythrocytes and in solution: influence of viscosity studied by ultrafast vibrational echo experiments.
- Fifth-order contributions to ultrafast spectrally resolved vibrational echoes: heme-CO proteins.
- Vibrational echo experiments on red blood cells: Comparison of the dynamics of cytoplasmic and aqueous hemoglobin.
- Myoglobin-CO substate structures and dynamics: multidimensional vibrational echoes and molecular dynamics simulations.
paper
- Structural basis for target discrimination and activation by Cas13d
- Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy
- Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system
- One-Pot Isothermal Linear Amplification and Cas12a-Based Nucleic Acid Detection
- Discovery and engineering of retrons for precise genome editing
- Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
- Unleashing high trans-substrate cleavage kinetics of Cas12a for nucleic acid diagnostics
- Mechanism of Cas9 inhibition by AcrIIA11
- Room temperature CRISPR diagnostics for low-resource settings
- PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
- Kinetic dissection of pre-crRNA binding and processing by CRISPR-Cas12a
- Massively Parallel Profiling of RNA-targeting CRISPR-Cas13d
- Mammalian Antigen Display for Pandemic Countermeasures
- High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL
- Asgard archaea defense systems and their roles in the origin of eukaryotic immunity
- CTCF and R-loops are boundaries of cohesin-mediated DNA looping
- Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
- In Diverse Conditions, Intrinsic Chromatin Condensates Have Liquid-like Material Properties
- Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons
- The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins
- Massively Parallel Selection of NanoCluster Beacons
- Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein
- How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
- Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
- A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
- Compartmentalization of telomeres through DNA-scaffolded phase separation
- Rapid characterization of spike variants via mammalian cell surface display
- Metagenomic Discovery of CRISPR-Associated Transposons
- Opfi: A Python package for identifying gene clusters in large genomics and metagenomics data sets
- Expression and characterization of SARS-CoV-2 Spike Proteins
- Characterization of the T4 gp32-ssDNA complex by native, cross-linking, and ultraviolet photodissociation mass spectrometry
- Disintegration promotes proto-spacer integration by the Cas1-Cas2 complex
- Trajectory of Growth of SARS-CoV-2 Variants in Houston, Texas, January through May 2021 Based on 12,476 Genome Sequences
- Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
- CRISPR-guided programmable self-assembly of artificial virus-like nucleocapsids
- Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
- Inhibition of CRISPR-Cas12a DNA Targeting by Nucleosomes and Chromatin
- Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area
- Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
- Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements
- Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes
- HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints
- RADX condenses single-stranded DNA to antagonize RAD51 loading
- DNA-dependent Protein Kinase Promotes DNA End Processing by MRN and CtIP
- Human cohesin compacts DNA by loop extrusion
- Systematic discovery of endogenous human ribonucleoprotein complexes
- Retrons and their applications in genome engineering
- Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
- RPA phosphorylation inhibits DNA resection
- Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
- Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
- Assembling the Human Resectosome on DNA Curtains.
- Sortase-mediated fluorescent labeling of CRISPR complexes
- Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.
- Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase
- Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.
- Assessing Protein Dynamics on Low-Complexity Single-Stranded DNA Curtains.
- Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.
- Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.
- Indel-correcting DNA barcodes for high-throughput sequencing.
- Coordination of Rad1-Rad10 interactions with Msh2-Msh3, Saw1 and RPA is essential for functional 3' non-homologous tail removal.
- Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair.
- A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.
- Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
- Eukaryotic resectosomes: A single-molecule perspective.
- Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips
- Efficient modification of λ-DNA substrates for single-molecule studies.
- An aging-independent replicative lifespan in a symmetrically dividing eukaryote.
- Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.
- Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.
- Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.
- Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.
- Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
- High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.
- High-throughput single-molecule studies of protein-DNA interactions.
- 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.
- From cradle to grave: high-throughput studies of aging in model organisms.
- Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.
- Rapid prototyping of multichannel microfluidic devices for single-molecule DNA curtain imaging.
- Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
- Molecular traffic jams on DNA.
- The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.
- Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.
- Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.
- Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.
- Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase.
- XPD helicase speeds through a molecular traffic jam.
- Single molecule studies of homologous recombination.
- Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy.
- Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: a new approach.
- Viscosity-Dependent Protein Dynamics
- Probing dynamics of complex molecular systems with ultrafast 2D IR vibrational echo spectroscopy.
- Substrate binding and protein conformational dynamics measured by 2D-IR vibrational echo spectroscopy.
- Cytochrome c552 mutants: structure and dynamics at the active site probed by multidimensional NMR and vibration echo spectroscopy.
- Dynamics of proteins encapsulated in silica sol-gel glasses studied with IR vibrational echo spectroscopy.
- The influence of aqueous versus glassy solvents on protein dynamics: vibrational echo experiments and molecular dynamics simulations.
- Ultrafast dynamics of myoglobin without the distal histidine: stimulated vibrational echo experiments and molecular dynamics simulations.
- Dynamics of hemoglobin in human erythrocytes and in solution: influence of viscosity studied by ultrafast vibrational echo experiments.
- Fifth-order contributions to ultrafast spectrally resolved vibrational echoes: heme-CO proteins.
- Vibrational echo experiments on red blood cells: Comparison of the dynamics of cytoplasmic and aqueous hemoglobin.
- Myoglobin-CO substate structures and dynamics: multidimensional vibrational echoes and molecular dynamics simulations.
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