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• 2025 O'Donnell Award in Biological Sciences: Ilya J. Finkelstein, Ph.D.
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• What is the B.1.1.7 COVID-19 variant, and how is UT-Austin reacting to its arrival?
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• Molecular Biologist Receives TAMEST O'Donnell Award
• Scientists Image DNA Repair Molecules
• New Gene-Editing Tech Holds Promise for Treating Complex Genetic Diseases
• Two Studies Shed Light on How Complex CRISPR Systems Work
• UT professor's gene editing research wins 2025 Edith and Peter O'Donnell Award
• UT researchers view interactions between DNA-repairing proteins
• COVID-19 vaccine innovation could dramatically speed up worldwide production
• New gene-editing tech holds promise for treating complex genetic diseases
• Potential new gene editing tools uncovered
• Ilya Finkelstein — Full CV
• CRISPR-Cas12a More Precise Than CRISPR-Cas9
• How to Encode The Wizard of Oz Into DNA
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• Ilya Finkelstein's Curriculum Vitae
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• The Finkelstein Lab
• Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein
• Massively Parallel Selection of NanoCluster Beacons
• Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips
• Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
• Unleashing high trans-substrate cleavage kinetics of Cas12a for nucleic acid diagnostics
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• Emily's Entourage Awards New Funding to University of Texas at Austin to Advance Breakthrough Gene Editing Therapy for Hard-to-Treat Cystic Fibrosis Mutations
• Science Thrives on Trust: Why Collaboration Is Our Greatest Strength
• All of Humanity's Knowledge Could Become Immortal Inside a Tiny Device—Powered by the Molecule That Built Life
• RIDDL: Rapid Inhibitor Discovery and Development PipeLine
• JGI announces final round of 2022 Functional Genomics awardees
• Two Assistant Profs Win Career Awards
• Cut, Paste, Cure
• Substrate binding and protein conformational dynamics measured by 2D-IR vibrational echo spectroscopy.
• Assessing Protein Dynamics on Low-Complexity Single-Stranded DNA Curtains.
• Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
• Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
• Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase.
• Human cohesin compacts DNA by loop extrusion
• Compartmentalization of telomeres through DNA-scaffolded phase separation
• Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes
• Massively Parallel Profiling of RNA-targeting CRISPR-Cas13d
• Kinetic dissection of pre-crRNA binding and processing by CRISPR-Cas12a
• High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.
• Systematic discovery of endogenous human ribonucleoprotein complexes
• From cradle to grave: high-throughput studies of aging in model organisms
• Asgard archaea defense systems and their roles in the origin of eukaryotic immunity
• Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.
• Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.
• Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area
• Expression and characterization of SARS-CoV-2 Spike Proteins
• Retrons and their applications in genome engineering
• The influence of aqueous versus glassy solvents on protein dynamics: vibrational echo experiments and molecular dynamics simulations
• Sortase-mediated fluorescent labeling of CRISPR complexes
• Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
• Dynamics of hemoglobin in human erythrocytes and in solution: influence of viscosity studied by ultrafast vibrational echo experiments.
• Cytochrome c552 mutants: structure and dynamics at the active site probed by multidimensional NMR and vibration echo spectroscopy
• Ultrafast dynamics of myoglobin without the distal histidine: stimulated vibrational echo experiments and molecular dynamics simulations
• RPA phosphorylation inhibits DNA resection
• Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.
• Myoglobin-CO substate structures and dynamics: multidimensional vibrational echoes and molecular dynamics simulations.
• Eukaryotic resectosomes: A single-molecule perspective.
• Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.
• DNA-dependent Protein Kinase Promotes DNA End Processing by MRN and CtIP
• High-throughput single-molecule studies of protein-DNA interactions.
• Intrinsically disordered regions regulate both catalytic and noncatalytic activities of the MutLα mismatch repair complex.
• Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.
• Efficient modification of λ-DNA substrates for single-molecule studies.
• Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.
• Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.
• CTCF and R-loops are boundaries of cohesin-mediated DNA looping
• Opfi: A Python package for identifying gene clusters in large genomics and metagenomics data sets
• HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints
• 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.
• Characterization of the T4 gp32-ssDNA complex by native, cross-linking, and ultraviolet photodissociation mass spectrometry
• Room temperature CRISPR diagnostics for low-resource settings
• Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
• Discovery and engineering of retrons for precise genome editing
• Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
• Single molecule studies of homologous recombination.
• Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
• A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
• The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins
• How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
• Structural basis for target discrimination and activation by Cas13d
• Indel-correcting DNA barcodes for high-throughput sequencing.
• Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy
• One-Pot Isothermal Linear Amplification and Cas12a-Based Nucleic Acid Detection
• Dynamics of proteins encapsulated in silica sol-gel glasses studied with IR vibrational echo spectroscopy.
• Probing dynamics of complex molecular systems with ultrafast 2D IR vibrational echo spectroscopy
• Trajectory of Growth of SARS-CoV-2 Variants in Houston, Texas, January through May 2021 Based on 12,476 Genome Sequences
• Viscosity-Dependent Protein Dynamics
• Mammalian Antigen Display for Pandemic Countermeasures
• In Diverse Conditions, Intrinsic Chromatin Condensates Have Liquid-like Material Properties
• Inhibition of CRISPR-Cas12a DNA Targeting by Nucleosomes and Chromatin
• High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL
• Coordination of Rad1-Rad10 interactions with Msh2-Msh3, Saw1 and RPA is essential for functional 3' non-homologous tail removal.
• Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair
• Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.
• Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: A new approach
• Mechanism of Cas9 inhibition by AcrIIA11
• Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
• Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
• CRISPR-guided programmable self-assembly of artificial virus-like nucleocapsids
• Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair.
• Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase
• RADX condenses single-stranded DNA to antagonize RAD51 loading
• Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system
• Molecular traffic jams on DNA.
• The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.
• Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy.
• PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
• Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
• Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons
• Rapid prototyping of multichannel microfluidic devices for single-molecule DNA curtain imaging
• XPD helicase speeds through a molecular traffic jam.
• Assembling the Human Resectosome on DNA Curtains.
• Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.
• Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements
• Rapid characterization of spike variants via mammalian cell surface display
• Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.
• Vibrational echo experiments on red blood cells: Comparison of the dynamics of cytoplasmic and aqueous hemoglobin
• Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
• Disintegration promotes proto-spacer integration by the Cas1-Cas2 complex
• Fifth-order contributions to ultrafast spectrally resolved vibrational echoes: heme-CO proteins.
• Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
• Metagenomic Discovery of CRISPR-Associated Transposons
• An aging-independent replicative lifespan in a symmetrically dividing eukaryote.
• A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.
• Scientists Develop Chip-Based Platform to Scan DNA for Off-Target CRISPR Effects
• UT coronavirus research could help speed up vaccine production
• Entire Wizard of Oz Novel Encoded Onto Strands of DNA
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• Scientists Encoded The Entire Wizard of Oz Into DNA
• SARS-CoV-2 Mutation May Partly Account for Fast Spread in Summer
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• Scientists just made gene editing far more powerful
• Making CRISPR more precise
• Powerful New DNA Editing Method Raises Hopes for Cures
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• UT scientists tinker with gene-mapping device to make DNA editing safe
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• Matching CRISPR to the Job Improves the Safety, Efficiency of the Gene-Editing Tool
• COVID-19 Vaccine Innovation Could Dramatically Speed Up Worldwide Production
• Coronavirus Mutation May Have Made It More Contagious
• Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies
• Potential New Gene Editing Tools Uncovered
• What is Academicons?